Podcast #19: Ending Aging, with Aubrey de Grey

“Aging is mostly the failure to repair.”–Gregory Benford

One man who agrees wholeheartedly with Gregory Benford is Aubrey de Grey.  He’s the author of Ending Aging, and chief science officer of the SENS Foundation, a 501-(c)(3) non-profit dedicated to researching the reversal of human aging.  His approach focuses on 7 areas of cellular and molecular damage, the repair of which he believes are be the keys to effective rejuvenation therapy. He joins me in this episode of Seeking Delphi™ for a lively discussion on the present state of the anti-aging art.

Links to relevant stories appear after the audio file and embedded YouTube video below.  A reminder that this and all Seeking Delphi ™podcasts are available on iTunes, PlayerFM, and has a channel on YouTube.  You can also follow us on Facebook

Follow me on twitter @MarkSackler

 

 

 

 

 

 

 

 

Episode #19, Ending Aging With Aubrey de Grey

YouTube slide show of Episode #19

 


Relevant links

Aubrey de Grey wikipedia bio

SENS Foundation

Elizabeth Parrish self-tests Bioviva gene therapy

Brian Hanley’s bold experiment

George Church’s ambitious plans

Laura Deming’s Longevity Fund

Information injected into monkey brains

Subscribe to Seeking Delphi™ on iTunes 

Subscribe to Seeking Delphi™ on PlayerFM

Subscribe on YouTube

Follow Seeking Delphi™ on Facebook @SeekingDelphi

Follow me on twitter @MarkSackler

The Future This Week: December 12, 2017

“The pace of progress on Mars depends upon the pace of progress of SpaceX.”–Elon Musk

Who will get there first?

Oh really, Elon?  It seems that Boeing may have something to say about that.  We got to the moon because of a frantic race between the U.S. and the Soviet Union, propelled by the cold war. If an when we get to Mars, it just might be because of a frantic race between commercial ventures, fueled by the almighty dollar.

 While you’re reading about all this week’s future-related  news, don’t forget that you can subscribe to Seeking Delphi™ podcasts on iTunes or PlayerFM, and you can also follow us on Twitter and Facebook 

Mars/Space Exploration–Speaking on CNBC recently, Boeing CEO Dennis Mullenberg said, “I firmly believe the first person to set foot on Mars will get there on a Boeing rocket.”  There was no immediate comment from Elon Musk, whose SpaceX aims to be there first.  Whoever gets there first, maybe they can getaround on the Tesla that Elon intends to launch into Mars orbit next year.

President Trump announced that the Moon will be the next destination for U.S. astronauts.  Whether he intends to put the treasury’s money where his mouth is remains to be seen.

Physics.org reports that a new space suit design will have a “take me home” button for astronauts who get separated from their craft and disoriented on space walks. Danger, Will Robinson!

Artificial Intelligence–The IEEE released the second edition of its global treatise on ethics of autonomous and intelligent systems, today.  The report can be requested for download here.   The report was mentioned in Seeking Delphi™ podcast episode #17, featuring an interview with the initiative’s executive director, John C. Havens.  (YouTube video  link below).

Researchers from the University of Texas and the city of Austin are employing deep learning and big data to try to alleviate traffic jams.  They will present their findings at an IEEE conference on big data later this month.

Using A.I. to alleviate traffic? Good!  Using A.I. to create fake porn of anybody?  Er–not so much.  The Verge reports that just a few photographs and some open source A.I. software is all that it takes to graft anybody’s face onto any picture in a convincing manner. As they put it, seeing may no longer be believing.

Biotech–Researchers at the Salk Institute say they have been able to use CRISPR gene editing to reverse disease in mice.  They used a new procedure that does not actually cut the genes, but affects the expression–or epigenetics–of genes. It turns them on or off.

Researchers at the University of Rochester say they have successfully been able to insert new information directly in the the pre-motor cortex of the brains of two monkeys.   Anyone for trying this on politicians?

Material Science/Athletics–British sportswear brand inov-8 is partnering with the University of Manchester to introduce graphene-infused athletic footwear in 2018.  Laboratory tests have shown the shoes to be stretchier, stronger and more wear resistant than conventional rubber-soled sneakers.

 

Aubry de Grey

Coming Attractions–SENS foundation co-founder and chief science officer, Aubrey de Grey, will join me for the final Seeking Delphi™ podcast interview of 2017.  Look for it in soon.

A reminder that the Seeking Delphi™ podcast is available on iTunesPlayerFM, blubrry , and has a channel on YouTube.  You can also follow us on Facebook.

The Future This Week: December 5, 2017

“The autonomous car is definitely coming…”–Masayoshi Son

Cars, cars, cars.  In America, we love our cars.  And, whether gas, electric, or hybrid, we love to drive them.  So what happens when they drive themselves?  And an even better question: when they get built in emotion A.I., will our cars love us?  OK, that last one is not a real issue–yet.  But every major car company is working on self-driving, all-electric cars.  The news this week is just full of cars, cars, cars.

 While you’re reading about all this week’s future-related  news, don’t forget that you can subscribe to Seeking Delphi™ podcasts on iTunes or PlayerFM, and you can also follow us on Twitter and Facebook 

 Self Driving Cars/Autonomous Vehicles–General Motors has announced plans to launch a self-driving, ride-sharing car service in major U.S. cities by 2019.  The aim is to compete directly with Uber and Lyft.

Uber is not standing idly by.  Volvo says they expect to sell them tens of thousands of self driving cars between 2019 and 2021.

Next Big Future reports that every major car company is working on all-electric, self-driving vehicles.   Ford, for one, also plans a self-driving, ride-sharing service by 2021.

What will Elon think of next?

Electric Vehicles–You can’t make this up, but apparently Elon Musk can.  He’s on record, and apparently serious, about launching a Tesla into orbit around Mars early next year.  The good news is, as long as it stays in orbit, it won’t need a charging station.

Ford’s chairman says they will introduce several electric car models in China over the next few years. He added that he expects China to be the leader in EV proliferation.

–According to recent reports, though, the Canadian province of Ontario will likely not reach its 2020 target for electric vehicle deployment.

Flying Cars/Taxis–Yeah, sure. Why should all the traffic jams be on the ground?  Volocopter says its flying taxis will be up (literally) and running in two to three years.

Space/Lunar Exploration–China has announced big plans for the moon.  A robotic lunar station, and a dark side radio telescope are targeted for 2019.

Brexit scenarios to 2030–The latest Seeking Delphi™ podcast features SAMI Consulting’s Jonathan Blanchard Smith discussing four post-Brexit scenarios for the UK.  (YouTube slide show link below)

Aubrey de Grey

Coming Attractions–SENS foundation co-founder and chief science officer, Aubrey de Grey, will join me for the final Seeking Delphi™ podcast interview of 2017.  Look for it in a few days.

A reminder that the Seeking Delphi™ podcast is available on iTunesPlayerFM, blubrry , and has a channel on YouTube.  You can also follow us on Facebook.

Podcast #18, U.K. 2030: Four Post-Brexit Scenarios

“Brexit was the first brick that was knocked out of the establishment wall.”–Nigel Farage

“Brexit was a fantastic example of a nation shooting itself in the face.”–Hugh Grant

 

Even as Trumpism continues to agitate and divide the U.S., Brexit continues to do the same in Britain. As the process plays out through lengthy and difficult negotiations, no particular outcome is clear. In this podcast episode #18 of Seeking Delphi™,  I talk with one of the architects of SAMI Consulting’s wide ranging report on 4 possible scenarios for Brexit, through 2030.  The future is murky, but one way or the other, it will get here.

Links to relevant stories appear after the audio file and embedded YouTube video below.  A reminder that this and all Seeking Delphi ™podcasts are available on iTunes, PlayerFM, and has a channel on YouTube.  You can also follow us on Facebook

Follow me on twitter @MarkSackler

 

 

 

 

 

 

 

 

Episode #18; U.K. 2030; Four Post-Brexit Scenarios

YouTube slide show of Episode #18

 

Jonathan Blanchard Smith, SAMI Consulting page

Brexit affects U.K. pharmaceuticals and healthcare

Brexit labor shortage could hit winemakers

Brexit Northern Ireland border issue

GM plans to launch autonomous ride-sharing program in 2019

California set to drop law that would limit self-driving vehicle manufacturer crash liability

Ontario to miss its 2020 electric vehicle targets.

Elon Musk’s SpaceX to orbit a Tesla vehicle around Mars–maybe.

 

Subscribe to Seeking Delphi™ on iTunes 

Subscribe to Seeking Delphi™ on PlayerFM

Subscribe on YouTube

Follow Seeking Delphi™ on Facebook @SeekingDelphi

Follow me on twitter @MarkSackler

The Future This Week: November 28, 2017

“Always make the audience suffer as much as possible.”–Alfred Hitchcock

It seems movie theater owners are taking Hitchcock quite literally.  At our first break from home binge watching in almost a year, my wife and I went to a local cinema. We arrived right on the dot at the advertised starting time of the movie, and immediately suffered through 20 minutes of commercials–exactly what we get away from by watching Amazon and Netflix and premium cable channels.  I just love paying to binge watch commercials.

 While you’re reading about all this week’s future-related  news, don’t forget that you can subscribe to Seeking Delphi™ podcasts on iTunes or PlayerFM, and you can also follow us on Twitter and Facebook 

Digital entertainmentAmazon, Apple, and Netflix  are expected to be spending nearly $20 Billion, combined, on digital content by 2022.  Take that, Bollywood.

The Venture Reality Fund reports that Hollywood’s investment in AR and VR is booming.  Overall, AR/VR investment in the second half of this year is seen as rising by $2.3 billion, or 79 per cent, over the same period a year ago.  Oh boy, even those insufferable commercials will be enhanced.

The worm turns–on mars.

Space Travel/Colonization–What’s better than pigs in space?  How about worms on Mars?  A recent study by researchers at Wageningen University found that earth worms can grow and reproduce in Martian-like soil. It’s part of a study to see if food plants can grow in the same compound, to support potential colonization.

–Woody Allen once said, “man can’t live on bread alone; often there must be a beverage.”  Anheiser-Busch is taking that literally by sending beer into space.  A Dec. 4 SpaceX launch will send beer making ingredients to the international space station, a very early step toward sending it to Mars with the first colonists.  Talk about opening new markets.

Future Life/2030 Forecasts–A new report from The World Economic Forum paints a heady picture of life in the year 2030.  Genetically engineered pets…smart toilets…internet connected clothes…wow, I can hardly wait.

 

A similar study, reported in Forbes, focuses more on how we will change as humans by 2030. It’s not about augmented reality, it’s about augmented us.

Transportation/Sustainable Energy–Hydrogen powered trains will be coming to Germany by 2021.  The technology is being built by French concern, Alstom.

Robotics/AI–China announced plans to open a fully automated police station, sans humans.  The facility will deal primarily with driving -related issues, making it more like a western motor vehicle department facility.  It’s all in line with China’s stated goal of being world leader in artificial intelligence by 203o.

A reminder that the Seeking Delphi™ podcast is available on iTunesPlayerFM, blubrry , and has a channel on YouTube.  You can also follow us on Facebook.

The Future This Week: November 20, 2017

 “There are nights when the wolves are silent and only the moon howls.” –George Carlin

Ah, the moon; so close, and yet so far away.  Has it really been almost fifty years since Neil Armstrong took his one small step for man?  Now, finally, the race is on to go back to our nearby celestial neighbor.  But in 1969, the only motivation was to win a race that was instigated by the cold war.  Now there is different driver in play.  It’s money;  many of the new players, in what is now a multi-way competition, are commercial ventures.

 While you’re reading about all this week’s future-related  news, don’t forget that you can subscribe to Seeking Delphi™ podcasts on iTunes or PlayerFM, and you can also follow us on Twitter and Facebook 

Space/Lunar explorationMoon Express has unveiled its lunar rover that’s due for a 2019 launch.  Described as an R2D2 lookalike, it would be the first commercial launch beyond earth orbit. The $20 million lunar X-Prize is hanging in the balance.

Yoda would be proud

China has announced plans to catch up to the US in space rocketry by the early 2020’s,  and a longer term goal of developing nuclear powered space vehicles by 2045.

Next big future reports on the possible development of what’s being called an interlunar photonic railway.  It’s based on the the laser powered space sails being planned by Breakthrough Starshot.

Electric Vehicles–Tesla unveiled two new ambitious vehicles, slated to begin production in 2019.  Its big-rig truck has a projected single-charge range of 500 miles and acceleration capabilities far better than diesel powered semis.  The roadster will boast a 620-mile range and a 260 mph top speed.  The price for these indulgences?  I’m not asking; i know I can’t afford either one.

Zoom Zoom

–Elon Musk may be the pioneer in all-electric vehicles, but he’s certainly not alone.  Volkswagon plans to invest an immodest $40 Billion on electric car technology through 2022,  and Toyota is targeting 2020 for its launch of an EV in China.

Senescence/Anti-aging research–Harvard professor and serial biotech entrepreneur Dr. George Church is moving headlong towards enabling human aging reversal.  His Rejuvenate Bio firm plans to test an age reversal therapy in dogs in 2019, and if successful, followed by human trials in 2022.

Scientists at Northwestern University say they have found what may be the first anti-aging genetic mutation.  The genetic anomaly was found in a small Amish community in Indiana.  Individuals who possess the mutation experience longer than average lifespans.

A reminder that the Seeking Delphi™ podcast is available on iTunesPlayerFM, blubrry , and has a channel on YouTube.  You can also follow us on Facebook.

Book Review: Life 3.0, Being Human In The Age of Artificial Intelligence, by Max Tegmark

“The short answer is obviously that we have no idea what will happen if humanity succeeds in building human-level AGI.”–Max Tegmark, in Life 3.0

 

Reprinted with permission of the publisher, my review of Max Tegmark’s new book, from the November/December issue of Age of Robots.

Full issue available for download here.

LIFE 3.0: BEING HUMAN IN THE AGE OF ARTIFICIAL INTELLIGENCE Max Tegmark ©2017, Borzoi Book published by Alfred A. Knopf, New York, 364p. Review by Mark Sackler

 

Max Tegmark is not one to shy away from bold scientific pronouncements. The MIT cosmologist and physics professor is perhaps best known for his taxonomy of a four level multiverse—some levels of which are predicted by certain theories, but none of which have been proven to exist. In his previous book, Our Mathematical Universe, My Quest for the Ultimate Nature of Reality, he offers the astounding conjecture that the whole of reality may be nothing more than pure mathematics.

So, what, if anything, makes Life 3.0, Being Human in The Age of Artificial Intelligence different? Unlike a universe of multiverses, or of pure mathematics, it deals with issues that are right in front of our faces. And his taxonomy of Life 1.0, 2.0 and 3.0 is not a mere conjecture that can’t yet— or might never—be tested. Artificial
intelligence is happening right in front of us, and we have a multiplicity of issues to deal with, while we still can control it. Even as Stephen Hawking and Elon Musk are shouting loudly about the potential dangers of artificial intelligence, and many actual AI researchers are countering that the dangers are overblown and distorted, Tegmark is doing something to bridge hype and reality. Or at least, he’s trying to. The problem is, there is no consensus even among the experts. He provides the reader with a wide range of scenarios. Many are not pretty—from a corporation using advanced AI to control global markets and ultimately governments, to a runaway AI that discards human intervention to rule the world itself. And yet, he asserts, all of the scenarios he presents have actual expert believers in their possibility.

The ultimate answer is, we don’t know. Tegmark is not so much warning against its development—it’s probably impossible to stop—as he is advising about its challenges, opportunities and dangers. He knows that the experts don’t really know, and neither does he. But he’s not afraid to present bold scenarios to awaken our awareness. He sums it up best in Chapter 5, Intelligence Explosion:

The short answer is obviously that we have no idea what will happen if humanity succeeds in building human-level AGI. For this reason, we’ve spent this chapter exploring a broad spectrum of scenarios. I’ve attempted to be quite inclusive, spanning the full range of speculations I’ve seen or heard discussed by AI researchers and technologists: fast takeoff/ slow takeoff/no takeoff, humans/ machines/cyborgs in control. I think it’s wise to be humble at this stage and acknowledge how little we know, because for each scenario discussed above, I know at least one well-respected AI researcher who views it as a real possibility.

Tegmark makes is clear, that for all the unknowns, we need to proceed with caution. Bold conjectures and scenarios sometimes turn into realities. And some of these potential realities are not where we want to go. Decisions we make about machine intelligence in the next few decades will go a long way to deciding the future of humanity—our evolution or even our continued existence. He goes on to present possible scenarios for what we might look like in 10,000 and even 1 Billion years. It’s fascinating, but mind-numbing. We simply might not be able to control any of it.

You can follow Seeking Delphi and me on Facebook and Twitter.